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Title :メソポーラスシリカ表面への ssDNA の修飾-DNAシグナル制御型分子ロボットに向けて-
Authors :古賀 朋代
宮元 展義
Issue Date :16-Apr-2020
Abstract :The outer surface of mesoporous silica (MCM-41) particles was modified with ssDNA attached with FAM (fluorescent moiety) and gate control of the pores was investigated. Infrared spectra confirmed the successful modification of MCM-41 with the ssDNA via 4 synthetic steps. To close the pore gate, the surface ssDNA was hybridized with linker ssDNA having complementary base sequence on both ends. The pore gate was then opened again by hybridization with the ssDNA having complementary base sequence only on one end and BHQ-1(fluorescence quencher) on the other end. The gate opening process was confirmed by observing the fluorescence quenching of the FAM on the surface-modified ssDNA caused by the BHQ-1.
Type Local :紀要論文
ISSN :24345725
Publisher :福岡工業大学総合研究機構
Comment :エレクトロニクス研究所(Electronics Research Laboratory)
URI :http://hdl.handle.net/11478/1528
citation :福岡工業大学総合研究機構研究所所報
Citation :福岡工業大学総合研究機構研究所所報 Vol.2 p.39 -43
Appears in Collections:Vol.2

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